Steeve did his PhD in Lyon, France studying Hepatitis C virus with Dr. Jean Pierre Lavergne and Dr. Francois Penin. He went on to a postdoc in Glasgow Scotland with Dr. John McLauchlan still studying Hepatitis C virus and did a second postdoc at Harvard medical School with Dr. Tom Kirchhausen and Dr. Max Nibert to study fundamental principles of virus entry into cells. He became group leader in 2012 in Heidelberg Germany. In 2022, he relocated his lab to the University of FLorida where his team studies the response of human intestinal epithelial cells to enteric pathogens, particularly enteric viruses.