{"id":382,"date":"2022-10-26T00:38:27","date_gmt":"2022-10-26T00:38:27","guid":{"rendered":"https:\/\/boulantlab.com\/?post_type=publications&#038;p=382"},"modified":"2022-10-26T13:44:09","modified_gmt":"2022-10-26T13:44:09","slug":"editorial-type-iii-interferons-emerging-roles-beyond-antiviral-barrier-defense","status":"publish","type":"publications","link":"https:\/\/boulantlab.com\/publications\/editorial-type-iii-interferons-emerging-roles-beyond-antiviral-barrier-defense\/","title":{"rendered":"Editorial: Type III interferons: Emerging roles beyond antiviral barrier defense"},"content":{"rendered":"\n<p>Type III interferons or IFN-\u03bbs, are composed of 4 members: IFN-\u03bb1, IFN-\u03bb2, IFN-\u03bb3, and IFN-\u03bb4. IFN-\u03bbs are master protectors against mucosal viral infections due to the preferential expression of their cognate receptor, IFNLR1, to cells of epithelial lineage and to a restricted pool of immune cells. IFN-\u03bb receptor activation induces intracellular signaling that overlaps with that of type I interferons (IFN-I) and culminates with the induction of Interferon-Stimulated-Genes (ISG) with antiviral functions. However, several studies have uncovered non-redundant functions of IFN-\u03bbs, compared to IFN-I, that go beyond viral restriction at epithelial barriers. In this topic, we highlighted several emerging aspects of IFN-\u03bb biology, including: their ability to restrict non-viral infections, the mechanisms by which they modulate immune responses, and the enigmatic role of human IFN-\u03bb4.<\/p>\n","protected":false},"featured_media":390,"template":"","_links":{"self":[{"href":"https:\/\/boulantlab.com\/wp-json\/wp\/v2\/publications\/382"}],"collection":[{"href":"https:\/\/boulantlab.com\/wp-json\/wp\/v2\/publications"}],"about":[{"href":"https:\/\/boulantlab.com\/wp-json\/wp\/v2\/types\/publications"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/boulantlab.com\/wp-json\/wp\/v2\/media\/390"}],"wp:attachment":[{"href":"https:\/\/boulantlab.com\/wp-json\/wp\/v2\/media?parent=382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}