The intestinal epithelium is composed of multiple cell types that are all derived from a unique stem cell niche. In this research axis, we are comparing how the different cell types respond to the same enteric pathogen challenge. We use a combination of organoid-model systems, high spatial-temporal resolution live microscopy, single cell transcriptomic approaches, and spatial transcriptomics of tissue to decipher how stem cells are rewired to create different intestinal lineages (e.g. enterocytes, goblet cells, Paneth cells, etc) that use different strategies to combat enteric viruses (e.g. different pathogen recognition receptors, different response to interferon, expression of different interferon stimulated genes (ISGs) etc). This characterization will allow us to better understand enteric pathogen tropism and cell type specific pharmacological interventions to combat infections or to regulate inflammatory bowel disease.